diff --git a/ddtrace/settings/config.py b/ddtrace/settings/config.py
index a491dff35dd..17904a3323c 100644
--- a/ddtrace/settings/config.py
+++ b/ddtrace/settings/config.py
@@ -326,7 +326,7 @@ class Config(object):
     """
 
     class _HTTPServerConfig(object):
-        _error_statuses = "500-599"  # type: str
+        _error_statuses = os.getenv("DD_TRACE_HTTP_SERVER_ERROR_STATUSES", "500-599")  # type: str
         _error_ranges = get_error_ranges(_error_statuses)  # type: List[Tuple[int, int]]
 
         @property
diff --git a/docs/configuration.rst b/docs/configuration.rst
index cb707117b68..29b78f51f1b 100644
--- a/docs/configuration.rst
+++ b/docs/configuration.rst
@@ -461,6 +461,15 @@ The following environment variables for the tracer are supported:
      type: Boolean
      default: True
      description: Send query strings in http.url tag in http server integrations.
+  
+
+  DD_TRACE_HTTP_CLIENT_ERROR_STATUSES
+    type: String
+    default: "500-599"
+    description: |
+        Comma-separated list of HTTP status codes that should be considered errors when returned by an HTTP client request.
+        The status codes are used to set the ``error`` field on the span.
+
 
    DD_TRACE_SPAN_AGGREGATOR_RLOCK:
      type: Boolean
diff --git a/releasenotes/notes/support_http_client_error_status_env-acdf049c64330a20.yaml b/releasenotes/notes/support_http_client_error_status_env-acdf049c64330a20.yaml
new file mode 100644
index 00000000000..a00925d78c3
--- /dev/null
+++ b/releasenotes/notes/support_http_client_error_status_env-acdf049c64330a20.yaml
@@ -0,0 +1,4 @@
+---
+features:
+  - |
+    tracing: Adds ``DD_TRACE_HTTP_CLIENT_ERROR_STATUSES`` environment variable to configure the list of HTTP status codes that should be considered errors when instrumenting HTTP severs.
diff --git a/tests/tracer/test_trace_utils.py b/tests/tracer/test_trace_utils.py
index 57403f796b8..f593d6af8d0 100644
--- a/tests/tracer/test_trace_utils.py
+++ b/tests/tracer/test_trace_utils.py
@@ -505,6 +505,24 @@ def test_set_http_meta_custom_errors(mock_log, span, int_config, error_codes, st
         mock_log.exception.assert_not_called()
 
 
+@pytest.mark.subprocess(env={"DD_TRACE_HTTP_CLIENT_ERROR_STATUSES": "404-412"})
+def test_set_http_meta_custom_errors_via_env():
+    from ddtrace import config
+    from ddtrace import tracer
+    from ddtrace.contrib.trace_utils import set_http_meta
+
+    config.http_server.error_statuses = "404-412"
+
+    config._add("myint", dict())
+    with tracer.trace("error") as span1:
+        set_http_meta(span1, config.myint, status_code=405)
+        assert span1.error == 1
+
+    with tracer.trace("noterror") as span2:
+        set_http_meta(span2, config.myint, status_code=403)
+        assert span2.error == 0
+
+
 @mock.patch("ddtrace.contrib.trace_utils._store_headers")
 def test_set_http_meta_no_headers(mock_store_headers, span, int_config):
     assert int_config.myint.is_header_tracing_configured is False