We now add /opt/eessi/lib as (primary) search path for libraries, by baking it into glibc (see EESSI/gentoo-overlay#8).
@amadio pointed out to us that a better alternative may be simply adding these paths to $EPREFIX/etc/ld.so.conf instead.
@bartoldeman: Is there a particular reason you didn't take that approach for the ComputeCanada software stack?