diff --git a/tests/test_controller.py b/tests/test_controller.py
index 1bb2dd9..4a6a591 100644
--- a/tests/test_controller.py
+++ b/tests/test_controller.py
@@ -1,5 +1,6 @@
 import asyncio
 import logging
+import weakref
 
 import pytest
 
@@ -76,6 +77,38 @@ def fn_3():
         controller.trigger = fn
 
 
+def test_weakrefs(controller):
+    class Obj:
+        method_call_count = 0
+        destructor_call_count = 0
+
+        def __del__(self):
+            Obj.destructor_call_count += 1
+
+        def fn(self):
+            Obj.method_call_count += 1
+            print("Obj.fn called")
+            return 1
+
+    o = Obj()
+
+    controller.func.add(weakref.WeakMethod(o.fn))
+
+    @controller.add("func")
+    def fn_1():
+        return 1.5
+
+    controller.func()
+    assert Obj.method_call_count == 1
+
+    del o
+
+    assert Obj.destructor_call_count == 1
+
+    controller.func()
+    assert Obj.method_call_count == 1
+
+
 @pytest.mark.asyncio
 async def test_tasks(controller):
     @controller.add("async_fn")
diff --git a/tests/test_state.py b/tests/test_state.py
index e2132e1..6220618 100644
--- a/tests/test_state.py
+++ b/tests/test_state.py
@@ -1,4 +1,5 @@
 import asyncio
+import weakref
 
 import pytest
 
@@ -339,3 +340,38 @@ def trigger_side_effect(**_):
     print(result)
 
     assert expected == result
+
+
+def test_weakref():
+    server = FakeServer()
+    state = State(commit_fn=server._push_state, hot_reload=True)
+    state.ready()
+
+    class Obj:
+        method_call_count = 0
+        destructor_call_count = 0
+
+        def __del__(self):
+            Obj.destructor_call_count += 1
+
+        def fn(self, *_args, **_kwargs):
+            Obj.method_call_count += 1
+            print("Obj.fn called")
+            return 1
+
+    o = Obj()
+
+    state.a = 1
+
+    state.change("a")(weakref.WeakMethod(o.fn))
+
+    state.a = 2
+    state.flush()
+    assert Obj.method_call_count == 1
+
+    del o
+    assert Obj.destructor_call_count == 1
+
+    state.a = 3
+    state.flush()
+    assert Obj.method_call_count == 1
diff --git a/trame_server/controller.py b/trame_server/controller.py
index ebc47a7..1b18602 100644
--- a/trame_server/controller.py
+++ b/trame_server/controller.py
@@ -1,4 +1,5 @@
 import logging
+import weakref
 
 from .utils import asynchronous, is_dunder, share
 from .utils.hot_reload import reload
@@ -7,6 +8,14 @@
 logger = logging.getLogger(__name__)
 
 
+def _safe_call(f, *args, **kwargs):
+    return (
+        f() and f()(*args, **kwargs)
+        if isinstance(f, weakref.WeakMethod)
+        else f(*args, **kwargs)
+    )
+
+
 class TriggerCounter:
     def __init__(self, init=0):
         self._count = init
@@ -333,17 +342,19 @@ def __call__(self, *args, **kwargs):
             else:
                 f = self.func
 
-            result = f(*args, **kwargs)
+            result = _safe_call(f, *args, **kwargs)
 
         if self.hot_reload:
             copy_list = list(map(reload, copy_list))
 
         # Exec added fn after
-        results = [f(*args, **kwargs) for f in copy_list]
+        results = [_safe_call(f, *args, **kwargs) for f in copy_list]
 
         # Schedule any task
         for task_fn in list(self.task_funcs):
-            results.append(asynchronous.create_task(task_fn(*args, **kwargs)))
+            results.append(
+                asynchronous.create_task(_safe_call(task_fn, *args, **kwargs))
+            )
 
         # Figure out return
         if self.func is None:
diff --git a/trame_server/state.py b/trame_server/state.py
index 67d1465..51c742f 100644
--- a/trame_server/state.py
+++ b/trame_server/state.py
@@ -1,5 +1,6 @@
 import inspect
 import logging
+import weakref
 
 from .utils import asynchronous, is_dunder, is_private, share
 from .utils.hot_reload import reload
@@ -162,7 +163,10 @@ def has(self, key):
         return result
 
     def setdefault(self, key, value):
-        """Set an initial value if the key is not present yet"""
+        """
+        Set an initial value if the key is not present yet
+        :returns the value in the state for the given key
+        """
         key = self._translator.translate_key(key)
         if key in self._pushed_state:
             return self._pushed_state[key]
@@ -279,7 +283,13 @@ def flush(self):
                 # Execute state listeners
                 self._state_listeners.add_all(_keys)
                 for fn in self._state_listeners:
-                    callback = fn
+                    if isinstance(fn, weakref.WeakMethod):
+                        callback = fn()
+                        if callback is None:
+                            continue
+                    else:
+                        callback = fn
+
                     if self._hot_reload:
                         if not inspect.iscoroutinefunction(callback):
                             callback = reload(callback)