diff --git a/readme.txt b/README.md similarity index 50% rename from readme.txt rename to README.md index dd3b583..13cc728 100644 --- a/readme.txt +++ b/README.md @@ -1,36 +1,41 @@ -NEURON mod files for CaT currents from the paper: -McRory et al., J.Biol.Chem. 276:3999 (2001). +# NEURON mod files for CaT currents from the paper: +McRory et al., *J.Biol.Chem.* 276:3999 (2001). -Running the kinetics.hoc simulation file will show +Running the kinetics.hoc simulation file will show the activation and inactivation steady-states and time constants of the three members of the LVA calcium channels family studied -in this paper (alpha-1G, -1H, and -1I), with kinetic parameters +in this paper (alpha-1G, -1H, and -1I), with kinetic parameters from functional expression in transfected cells. Parameters for activation/inactivation are from the paper. However, not all the parameters used to fit (with single exponentials) -the experimental values for the time constants were given in the paper. -Those explicitly reported were used to constrain a fit +the experimental values for the time constants were given in the paper. +Those explicitly reported were used to constrain a fit of experimental values derived from Fig.6. -Ca++ reversal potential is calculated from Nerst equation, using +Ca++ reversal potential is calculated from Nernst equation, using internal and external Ca++ concentrations. Default values are [Ca]i=50nM and [Ca]o=2mM. -Under unix systems: -to compile the mod files use the command -nrnivmodl -and run the simulation hoc file with the command -nrngui kinetics.hoc +## Under Unix systems: +To compile the mod files use the command +`nrnivmodl` -Under Windows: -to compile the mod files use the "mknrndll" command. +and run the simulation hoc file with the command +`nrngui kinetics.hoc` + +## Under Windows: +To compile the mod files use the "mknrndll" command. A double click on the simulation file -kinetics.hoc +`kinetics.hoc` will open the simulation window. -Questions on the model parameters should be directed to the +Questions on the model parameters should be directed to the authors of paper. Questions on how to use this model with NEURON should be directed to michele@pa.ibf.cnr.it + +--- + +2025-05-27 – Standardized to Markdown. \ No newline at end of file