From 762cd528beec1dd44f84e468e3fb75a848ba718c Mon Sep 17 00:00:00 2001 From: yhy808 <123591630+yhy808@users.noreply.github.com> Date: Wed, 2 Oct 2024 18:06:39 -0400 Subject: [PATCH 1/2] convert txt file to markdown --- readme.txt => readme.md | 22 +++++++++++----------- 1 file changed, 11 insertions(+), 11 deletions(-) rename readme.txt => readme.md (73%) diff --git a/readme.txt b/readme.md similarity index 73% rename from readme.txt rename to readme.md index 2911d16..5559d58 100644 --- a/readme.txt +++ b/readme.md @@ -4,38 +4,38 @@ Hyperpolarization-activated, mixed-cation current (Ih) in octopus cells of the mammalian Cochlear Nucleus, J. Neurophysiol. 84, 806-817 (2000) -The current has been modeled as two independent HH-like gates +- The current has been modeled as two independent HH-like gates with the same activation curve but different time constants (fast and slow). The two gates are added to give the current as : + ``` i_hcno = gbar_hcno*(v-eh)*(h1*frac+h2*(1-frac)) ``` -i_hcno = gbar_hcno*(v-eh)*(h1*frac+h2*(1-frac)) - -Running the kinetics.hoc simulation file will show +- Running the kinetics.hoc simulation file will show the activation steady-state, the time constants, a simple simulation using a somatic current injection of -1.3nA, and a family of curves generated modeling the same protocol used in the experiments for Fig.6A of the paper. For Fig.6A the peak conductance has been adjusted to give approximately the same currents shown in the paper. -The time constants reported in the paper are shown +- The time constants reported in the paper are shown as markers of different colors. Time constants in the range not covered by the paper are an arbitrary extension. -By changing the frac and color parameters +- By changing the frac and color parameters one can model the relative percentage of fast and slow gates. -Under unix systems: +## Under unix systems: to compile the mod files use the command -nrnivmodl +``` nrnivmodl ``` and run the simulation hoc file with the command -nrngui kinetics.hoc +``` nrngui kinetics.hoc ``` -Under Windows using NEURON 5.1: +## Under Windows using NEURON 5.1: to compile the mod files use the "mknrndll" command. A double click on the simulation file kinetics.hoc will open the simulation window. +\ Questions on how to use this model should be directed to -michele.migliore@pa.ibf.cnr.it \ No newline at end of file +michele.migliore@pa.ibf.cnr.it From 5e362f9bcfb8ba425854fa85801cb6981c622102 Mon Sep 17 00:00:00 2001 From: yhy808 <123591630+yhy808@users.noreply.github.com> Date: Sun, 6 Oct 2024 11:28:52 -0400 Subject: [PATCH 2/2] added changelog and put journal name in Italics --- readme.md | 6 +++++- 1 file changed, 5 insertions(+), 1 deletion(-) diff --git a/readme.md b/readme.md index 5559d58..f965021 100644 --- a/readme.md +++ b/readme.md @@ -2,7 +2,7 @@ NEURON mod files for the Ih current from the paper: R. Bal and D. Oertel Hyperpolarization-activated, mixed-cation current (Ih) in octopus cells of the mammalian Cochlear Nucleus, -J. Neurophysiol. 84, 806-817 (2000) +*J. Neurophysiol.* 84, 806-817 (2000) - The current has been modeled as two independent HH-like gates with the same activation curve but different time constants (fast and slow). @@ -39,3 +39,7 @@ will open the simulation window. \ Questions on how to use this model should be directed to michele.migliore@pa.ibf.cnr.it + +Changelog: +---------- +2024-10: converted readme to markdown