diff --git a/README.md b/README.md new file mode 100644 index 0000000..1d500d7 --- /dev/null +++ b/README.md @@ -0,0 +1,43 @@ +# NEURON mod files for the K-A current + +From the papers: +Benison et al., *J. Theor. Biol.* 210:187 (2001) (model) and +Skaliora, et al., *Eur. J. Neurosci.* 7:1558-1568 (1995) (exp.). + +Running the **kinetics.hoc** simulation file will show +the activation and inactivation steady-states, the time constants, +and a family of curves generated modeling the same protocols +used for Figs. 8B of the experimental paper. + +The kinetic parameters used here are from the modeling paper. +They were chosen by the authors to fit the time course +of the current obtained from whole-cell data in their own +laboratory (experimental paper). + +The peak conductance has been adjusted to give approximately the +same peak currents shown in the experiments. + +## Under Unix systems: + +To compile the mod files use the command +`nrnivmodl` + +and run the simulation hoc file with the command +`nrngui kinetics.hoc` + +## Under Windows using NEURON 5.1: + +To compile the mod files use the **mknrndll** command. +A double click on the simulation file +**kinetics.hoc** +will open the simulation window. + +Questions on the model parameters should be directed to the +authors of the modeling paper. + +Questions on how to use this model with NEURON +should be directed to michele@pa.ibf.cnr.it + +--- + +2025-05-27 – Standardized to Markdown \ No newline at end of file diff --git a/readme.txt b/readme.txt deleted file mode 100644 index 247f4a6..0000000 --- a/readme.txt +++ /dev/null @@ -1,34 +0,0 @@ -NEURON mod files for the K-A current from the papers: -Benison et al., J.Theor.Biol. 210:187 (2001) (model) and -Skaliora, et al., Eur.J.Neurosci. 7:1558-1568 (1995) (exp.). - -Running the kinetics.hoc simulation file will show -the activation and inactivation steady-states, the time constants, -and a family of curves generated modeling the same protocols -used for Figs.8B of the experimental paper. - -The kinetic parameters used here are from the modeling paper. -They where chosen by the authors to fit the time course -of the current obtained from whole-cell data in their own -laboratory (experimental paper). - -The peak conductance has been adjusted to give approximately the -same peak currents shown in the experiments. - -Under unix systems: -to compile the mod files use the command -nrnivmodl -and run the simulation hoc file with the command -nrngui kinetics.hoc - -Under Windows using NEURON 5.1: -to compile the mod files use the "mknrndll" command. -A double click on the simulation file -kinetics.hoc -will open the simulation window. - -Questions on the model parameters should be directed to the -authors of the modeling paper. - -Questions on how to use this model with NEURON -should be directed to michele@pa.ibf.cnr.it