DOMINO is an active module identification algorithm (which is broadly categorized in SPRAS under 'disease mining algorithms'). See the associated paper: https://doi.org/10.15252/msb.20209593 and the associated MIT-licensed codebase: https://github.com/Shamir-Lab/DOMINO/.
DOMINO has two optional parameters:
- slice_threshold: the p-value threshold for considering a slice as relevant
- module_threshold: the p-value threshold for considering a putative module as final module
DOMINO requires the active column to be set. DOMINO does not consider edge weights, but DOMINO does consider graph directionality.
If the input dataframe is empty or too 'small' (where no modules are found), SPRAS will instead emit an empty output file.