diff --git a/.github/workflows/ElastixGitHubActions.yml b/.github/workflows/ElastixGitHubActions.yml
index 5b07aceaa..fac70b15c 100644
--- a/.github/workflows/ElastixGitHubActions.yml
+++ b/.github/workflows/ElastixGitHubActions.yml
@@ -15,7 +15,7 @@ jobs:
             cxx-compiler: "g++"
             libtorch-cpu-url: "https://download.pytorch.org/libtorch/cpu/libtorch-shared-with-deps-2.8.0%2Bcpu.zip"
             cuda-version: "cpu"
-            itk-git-tag: "v5.4.5"
+            itk-git-tag: "v5.4.6"
             cmake-build-type: "Release"
             libs:
               - elastix-build/bin/libelx-ANNlib.so
@@ -25,7 +25,7 @@ jobs:
             cxx-compiler: "cl.exe"
             libtorch-cpu-url: "https://download.pytorch.org/libtorch/cpu/libtorch-win-shared-with-deps-2.8.0%2Bcpu.zip"
             cuda-version: "cpu"
-            itk-git-tag: "v5.4.5"
+            itk-git-tag: "v5.4.6"
             cmake-build-type: "Release"
             libs:
               - elastix-build/bin/elx-ANNlib.dll
@@ -36,7 +36,7 @@ jobs:
             cxx-compiler: "clang++"
             libtorch-cpu-url: "https://download.pytorch.org/libtorch/cpu/libtorch-macos-arm64-2.8.0.zip"
             cuda-version: "cpu"
-            itk-git-tag: "v5.4.5"
+            itk-git-tag: "v5.4.6"
             cmake-build-type: "Release"
             libs:
               - elastix-build/bin/libelx-ANNlib.dylib
diff --git a/.github/workflows/publish-elastix.yml b/.github/workflows/publish-elastix.yml
index 8e61ac49d..25f499077 100644
--- a/.github/workflows/publish-elastix.yml
+++ b/.github/workflows/publish-elastix.yml
@@ -15,7 +15,7 @@ jobs:
             libtorch-cpu-url: "https://download.pytorch.org/libtorch/cpu/libtorch-shared-with-deps-2.8.0%2Bcpu.zip"
             libtorch-cuda-url: "https://download.pytorch.org/libtorch/cu128/libtorch-shared-with-deps-2.8.0%2Bcu128.zip"
             cuda_toolkit_version: '12.8.0'
-            itk-git-tag: "v5.4.5"
+            itk-git-tag: "v5.4.6"
             c-compiler: "gcc"
             cxx-compiler: "g++"
             cmake-build-type: "Release"
@@ -25,7 +25,7 @@ jobs:
             libtorch-cpu-url: "https://download.pytorch.org/libtorch/cpu/libtorch-win-shared-with-deps-2.8.0%2Bcpu.zip"
             libtorch-cuda-url: "https://download.pytorch.org/libtorch/cu128/libtorch-win-shared-with-deps-2.8.0%2Bcu128.zip"
             cuda_toolkit_version: '12.8.0'
-            itk-git-tag: "v5.4.5"
+            itk-git-tag: "v5.4.6"
             c-compiler: "cl.exe"
             cxx-compiler: "cl.exe"
             cmake-build-type: "Release"
@@ -36,7 +36,7 @@ jobs:
             c-compiler: "clang"
             cxx-compiler: "clang++"
             libtorch-cpu-url: "https://download.pytorch.org/libtorch/cpu/libtorch-macos-arm64-2.8.0.zip"
-            itk-git-tag: "v5.4.5"
+            itk-git-tag: "v5.4.6"
             cmake-build-type: "Release"
             libs:
               - elastix-build/bin/libelx-ANNlib.dylib
diff --git a/Common/GTesting/CMakeLists.txt b/Common/GTesting/CMakeLists.txt
index d10d1bbc8..a24713ece 100644
--- a/Common/GTesting/CMakeLists.txt
+++ b/Common/GTesting/CMakeLists.txt
@@ -35,7 +35,7 @@ target_compile_definitions(CommonGTest PRIVATE
   ELX_CMAKE_CURRENT_BINARY_DIR="${CMAKE_CURRENT_BINARY_DIR}"
 )
 
-if (ITK_VERSION VERSION_LESS_EQUAL 5.4.5)
+if (ITK_VERSION VERSION_LESS_EQUAL 5.4.6)
   target_link_libraries(CommonGTest
     GTest::GTest
     GTest::Main
diff --git a/Core/Main/GTesting/CMakeLists.txt b/Core/Main/GTesting/CMakeLists.txt
index f2bd9d210..f01c28c7d 100644
--- a/Core/Main/GTesting/CMakeLists.txt
+++ b/Core/Main/GTesting/CMakeLists.txt
@@ -12,7 +12,7 @@ target_compile_definitions(ElastixLibGTest PRIVATE
   _USE_MATH_DEFINES # For M_PI.
 )
 
-if (ITK_VERSION VERSION_LESS_EQUAL 5.4.5)
+if (ITK_VERSION VERSION_LESS_EQUAL 5.4.6)
   target_link_libraries(ElastixLibGTest
     GTest::GTest
     GTest::Main
diff --git a/Testing/CI/Azure/ci.yml b/Testing/CI/Azure/ci.yml
index 626a1be6e..db065e6a1 100644
--- a/Testing/CI/Azure/ci.yml
+++ b/Testing/CI/Azure/ci.yml
@@ -1,5 +1,5 @@
 variables:
-  ITKv5_VERSION: v5.4.5
+  ITKv5_VERSION: v5.4.6
   ITK_GIT_URL: https://github.com/InsightSoftwareConsortium/ITK
   LIBTORCH_BINARY_URL_WIN: https://download.pytorch.org/libtorch/cpu/libtorch-win-shared-with-deps-2.6.0%2Bcpu.zip
   LIBTORCH_BINARY_URL_LINUX: https://download.pytorch.org/libtorch/cpu/libtorch-cxx11-abi-shared-with-deps-2.6.0%2Bcpu.zip