Development and Optimization of a 43 Gene Pharmacogenomic Panel Using Enrichment-Based Capture and PacBio HiFi Sequencing
Abstract #: 2021-A-1822-ASHG Daniel Portik [1], Ting Hon [1], Josiah Wilcots [1], Nina Gonzaludo [1], Yao Yang [2,3], Nathan A. Hammond [3], Zev Kronenberg [1], Nathaniel Watson [3], John Harting [1], Euan Ashley [4], Janet Ziegle [1], Stuart A. Scott [2,3], Sarah Kingan [1]
1. PacBio, 1305 O’Brien Drive, Menlo Park, CA 94025; 2. Department of Pathology, Stanford University, Stanford, CA 94305; 3. Clinical Genomics Laboratory, Stanford Health Care, Palo Alto, CA 94304; 4. Stanford Center for Inherited Cardiovascular Disease, Stanford, CA, 94305
Introduction Sample Preparation, Capture, and Sequencing Results
| *4 VCF 00276 4/*5 *5 12kb deletion |
Col2 | Col3 |
|---|---|---|
| *4 VCF *5 12kb deletion 00276 4/*5 |
*4 VCF | |
| *4 VCF *5 12kb deletion 00276 4/*5 |
||
| *5 12kb deletion |
| Pharmacogenomics Panel ABCB1 CYP4F2 MTHFR ABCG2 DPYD NAT2 |
Col2 | Col3 |
|---|---|---|
| ADRA2A | DRD2 | NUDT15 |
| APOL1 | F2 | OPRD1 |
| BCHE | F5 | OPRK1 |
| COMT |
G6PD |
OPRM1 |
| CTBP2P2 CYP1A2 CYP2B6 CYP2C19 |
GRIK4 HLA-A HLA-B HLA-DQA1 |
SLC6A4 SLCO1B1 TPMT UGT1A1 |
| CYP2C8 CYP2C9 CYP2D6 CYP3A4 |
HLA-DRB1 HTR2A HTR2C IFNL3 |
UGT2B15 VKORC1 YEATS4 |
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