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Citation

Primary Citation

If you use this code or methodology in your research, please cite our preprint:

Preprint Paper:

BibTeX Entry

@article{AD_PAC_2026,
  title={Phase-Amplitude Coupling Analysis in Alzheimer's Disease},
  author={[Authors to be filled from paper]},
  journal={medRxiv},
  year={2026},
  doi={10.64898/2026.02.06.26345635},
  url={https://www.medrxiv.org/content/10.64898/2026.02.06.26345635v1}
}

Additional Citations

PAC Method

The PAC estimation code is based on the method developed by:

Pellegrini, F., Nguyen, T.D., Herrera,T., Nikulin, V., Nolte, G., & Haufe, S. (2023). Distinguishing between- from within-site phase-amplitude coupling using antisymmetrized bispectra. bioRxiv 2023.10.26.564193. https://doi.org/10.1101/2023.10.26.564193

Code Repository: https://github.com/fpellegrini/PAC

Required Toolboxes

If you use the toolboxes employed in this pipeline, please also cite:

FieldTrip

Oostenveld, R., Fries, P., Maris, E., & Schoffelen, J. M. (2011). FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Computational Intelligence and Neuroscience, 2011.

@article{oostenveld2011fieldtrip,
  title={FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data},
  author={Oostenveld, Robert and Fries, Pascal and Maris, Eric and Schoffelen, Jan-Mathijs},
  journal={Computational Intelligence and Neuroscience},
  volume={2011},
  year={2011},
  publisher={Hindawi}
}

Brainstorm

Tadel, F., Baillet, S., Mosher, J. C., Pantazis, D., & Leahy, R. M. (2011). Brainstorm: a user-friendly application for MEG/EEG analysis. Computational Intelligence and Neuroscience, 2011.

@article{tadel2011brainstorm,
  title={Brainstorm: a user-friendly application for MEG/EEG analysis},
  author={Tadel, Fran{\c{c}}ois and Baillet, Sylvain and Mosher, John C and Pantazis, Dimitrios and Leahy, Richard M},
  journal={Computational Intelligence and Neuroscience},
  volume={2011},
  year={2011},
  publisher={Hindawi}
}

FreeSurfer

Dale, A. M., Fischl, B., & Sereno, M. I. (1999). Cortical surface-based analysis: I. Segmentation and surface reconstruction. NeuroImage, 9(2), 179-194.

@article{dale1999cortical,
  title={Cortical surface-based analysis: I. Segmentation and surface reconstruction},
  author={Dale, Anders M and Fischl, Bruce and Sereno, Martin I},
  journal={NeuroImage},
  volume={9},
  number={2},
  pages={179--194},
  year={1999},
  publisher={Elsevier}
}

Data Availability

The MEG and MRI data used in this study are available at:

Software Availability

The source code for this project is available at: