diff --git a/adb_cli/src/models/adb_cli_error.rs b/adb_cli/src/models/adb_cli_error.rs
index 9a04215..e479fcf 100644
--- a/adb_cli/src/models/adb_cli_error.rs
+++ b/adb_cli/src/models/adb_cli_error.rs
@@ -77,7 +77,8 @@ impl From<adb_client::RustADBError> for ADBCliError {
             | RustADBError::ADBShellNotSupported
             | RustADBError::USBDeviceNotFound(_, _)
             | RustADBError::WrongFileExtension(_)
-            | RustADBError::AddrParseError(_) => Self::Standard(value),
+            | RustADBError::AddrParseError(_)
+            | RustADBError::DeviceBusy => Self::Standard(value),
         }
     }
 }
diff --git a/adb_client/src/error.rs b/adb_client/src/error.rs
index c1da179..94859af 100644
--- a/adb_client/src/error.rs
+++ b/adb_client/src/error.rs
@@ -74,6 +74,11 @@ pub enum RustADBError {
     #[cfg_attr(docsrs, doc(cfg(feature = "usb")))]
     #[error("USB Error: {0}")]
     UsbError(#[from] rusb::Error),
+    /// Selected device is busy.
+    #[cfg(feature = "usb")]
+    #[cfg_attr(docsrs, doc(cfg(feature = "usb")))]
+    #[error("Device is busy. Is ADB server running?")]
+    DeviceBusy,
     /// USB device not found
     #[error("USB Device not found: {0} {1}")]
     USBDeviceNotFound(u16, u16),
diff --git a/adb_client/src/message_devices/usb/usb_transport.rs b/adb_client/src/message_devices/usb/usb_transport.rs
index 099c845..74a1d78 100644
--- a/adb_client/src/message_devices/usb/usb_transport.rs
+++ b/adb_client/src/message_devices/usb/usb_transport.rs
@@ -92,8 +92,12 @@ impl USBTransport {
     }
 
     fn configure_endpoint(handle: &DeviceHandle<GlobalContext>, endpoint: &Endpoint) -> Result<()> {
-        handle.claim_interface(endpoint.iface)?;
-        Ok(())
+        match handle.claim_interface(endpoint.iface) {
+            Ok(()) => Ok(()),
+            // busy state likely indicates an ADB server is running and has taken the lock over the device
+            Err(rusb::Error::Busy) => Err(RustADBError::DeviceBusy),
+            Err(err) => Err(err.into()),
+        }
     }
 
     fn find_endpoints(handle: &DeviceHandle<GlobalContext>) -> Result<(Endpoint, Endpoint)> {
@@ -185,6 +189,11 @@ impl ADBTransport for USBTransport {
     }
 
     fn disconnect(&mut self) -> crate::Result<()> {
+        if self.handle.is_none() {
+            // device has not been initialized, nothing to do
+            return Ok(());
+        }
+
         let message = ADBTransportMessage::try_new(MessageCommand::Clse, 0, 0, &[])?;
         if let Err(e) = self.write_message(message) {
             log::error!("error while sending CLSE message: {e}");