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---
layout: default
---
<div class="header-container jumbotron" style="
padding-bottom: 10px;
background-image: linear-gradient(to right, rgba(0, 23, 79, 1), rgba(0, 23, 79, 0.8), rgba(0, 23, 79, 0.5)), url(./assets/gene.jpeg);
background-blend-mode: initial;
background-size: cover;
background-position: top;
margin-top: -70px !important;
box-shadow: rgba(0, 0, 0, 0.15) 0px 1rem 4rem;
">
<!-- COVID announcement removed
<div class="banner" style="background-color: red">
<span style="display: inline-block;
text-align: center;
width: 100%; padding-top: 15px;">
<i class="fa-solid fa-3x fa-exclamation-triangle" style="display: inline-block;
text-align: left;
font-size: 25px;"></i>
<a href="/covid-19.html" style="color:white; font-size: 14px;">
COVID-19 pandemic: click here to get GO data on SARS-CoV-2
</a>
</span>
</div>
-->
<div class="container" style="width: 98%;">
<div class="container" style="width: 98%; padding-top: 50px;">
<p style="color: #f2be54;
font-size: 13px;
text-align: right;
letter-spacing: 0.35rem;
padding: 0px;
padding-right: 1em;
margin-bottom: 10px;
/* transform: translateY(-25px); */
transform: translate(50px, -25px);
/* background-color: white; */
/* text-shadow: 1px 1px black;*/">
Current release <span id="id_release_date" class="header_stat"></span>:
<span id="id_terms" class="header_stat"></span> GO terms |
<span id="id_annotations" class="header_stat"></span> annotations<br>
<span id="id_geneproducts" class="header_stat"></span> gene products |
<span id="id_species" class="header_stat"></span> species
<span style="text-align: right; margin-left: 5px;">
(<a href="/stats.html" style="color: cyan;">see statistics</a>)
</span>
</p>
<h1 class="site__title" style="
font-size: 45px;
letter-spacing: 0.35rem;
text-transform: uppercase;
font-weight: 400;">The Gene Ontology Resource</h1>
<div class="row">
<div class="col-md-8">
<p class="site__statement" style="font-size: 16px; max-width: 820px; margin-bottom: 0px; text-align: justify;">
The mission of the GO Consortium is to develop a comprehensive,
<b>computational model of biological systems</b>, ranging from the molecular to the organism level, across the multiplicity
of species in the tree of life.
<br>
<br> The Gene Ontology (GO) knowledgebase is the world’s largest source of information on the functions of genes. This
knowledge is both human-readable and machine-readable, and is a foundation for computational analysis of large-scale
molecular biology and genetics experiments in biomedical research.
</p>
<br>
<p>
<form action="https://amigo.geneontology.org/amigo/medial_search" class="" method="GET" name="form-search" target="_blank"
style="max-width: 810px;">
<div class="center-block" style="padding-bottom: 1em;">
<div class="input-group">
<input id="gsf-query" class="form-control input-lg go-search-bar" style="width: 100%; border-radius:25px 0px 0px 25px;height: 50px; font-size: 16px;"
name="q" placeholder="Search GO term or Gene Product in AmiGO ..." title="Hint: add a space after completing a word to narrow the search."
type="text">
<span class="input-group-btn">
<button class="btn btn-primary u-no-transform go-search-bar u-anim-zoom-in" type="submit" style="padding-left: 15px; padding-right: 15px; border-radius:0px 25px 25px 0px; height: 50px; background-color: #22612C; border-color: #22612C;" title="Search for GO terms or Gene Products">
<i class="fa-solid fa-search"></i>
</button>
</span>
</div>
<div style="color:white; margin-top: 5px; margin-left:10px; font-size: 16px">
<input type="radio" name="searchtype" value="all" checked="checked"> Any
<input type="radio" name="searchtype" value="ontology"> Ontology
<input type="radio" name="searchtype" value="geneproduct"> Gene Product
</div>
</div>
</form>
</p>
</div>
<div class="col-md-4" style="transform: translateY(-15px);">
<h3 style="display: block; margin-left: auto; margin-right: auto; font-size: 24px; letter-spacing: 0.18rem; margin-top: 0px; margin-bottom: 0px; ">
<a href="/docs/go-enrichment-analysis/" style="color:white; font-size: 22px;">GO Enrichment Analysis
<i class="fa-solid fa-question-circle"></i>
</a>
</h3>
<i style="
width: 100%;
display: block;
font-size: 14px;">Powered by <a href="https://pantherdb.org" style="color: white" target="blank">PANTHER</a></i>
<form action="https://pantherdb.org/webservices/go/overrep.jsp" class="form-inline" role="form" method="POST" target="_blank">
<input name="correction" value="fdr" type="hidden">
<input name="format" value="html" type="hidden">
<input name="resource" value="PANTHER" type="hidden">
<textarea id="landing_gene_input" class="form-control" rows="6" name="input" placeholder="Your gene IDs here..." style="width:100%; resize: none; margin-bottom: 5px; font-size: 14px;"></textarea>
<div class="form-group" style="width:100%;margin-bottom: 5px;">
<select id="rte_ontology" class="form-control" name="ontology" style="width:100%">
<option value="biological_process">biological process</option>
<option value="molecular_function">molecular function</option>
<option value="cellular_component">cellular component</option>
</select>
</div>
<div class="input-group">
<div class="form-group">
<select id="rte_species" class="form-control" name="species" style="width: 100%;">
<option value="HUMAN">Homo sapiens</option>
<option value="MOUSE">Mus musculus</option>
<option value="RAT">Rattus norvegicus</option>
<option value="CHICK">Gallus gallus</option>
<option value="DANRE">Danio rerio</option>
<option value="DROME">Drosophila melanogaster</option>
<option value="CAEEL">Caenorhabditis elegans</option>
<option value="YEAST">Saccharomyces cerevisiae</option>
<option value="SCHPO">Schizosaccharomyces pombe</option>
<option value="DICDI">Dictyostelium discoideum</option>
<option value="ARATH">Arabidopsis thaliana</option>
<option value="ECOLI">Escherichia coli</option>
<option value="EMENI">Emericella nidulans</option>
<option value="AMBTC">Amborella trichopoda</option>
<option value="ANOCA">Anolis carolinensis</option>
<option value="ANOGA">Anopheles gambiae</option>
<option value="AQUAE">Aquifex aeolicus</option>
<option value="ASHGO">Ashbya gossypii</option>
<option value="BACCR">Bacillus cereus</option>
<option value="BACSU">Bacillus subtilis</option>
<option value="BACTN">Bacteroides thetaiotaomicron</option>
<option value="BATDJ">Batrachochytrium dendrobatidis</option>
<option value="BOVIN">Bos taurus</option>
<option value="BRADI">Brachypodium distachyon</option>
<option value="BRADU">Bradyrhizobium diazoefficiens</option>
<option value="BRAFL">Branchiostoma floridae</option>
<option value="BRARP">Brassica rapa subsp. pekinensis</option>
<option value="CAEBR">Caenorhabditis briggsae</option>
<option value="CANAL">Candida albicans</option>
<option value="CANLF">Canis lupus familiaris</option>
<option value="CHLTR">Chlamydia trachomatis</option>
<option value="CHLRE">Chlamydomonas reinhardtii</option>
<option value="CHLAA">Chloroflexus aurantiacus</option>
<option value="CIOIN">Ciona intestinalis</option>
<option value="CITSI">Citrus sinensis</option>
<option value="CLOBH">Clostridium botulinum</option>
<option value="COXBU">Coxiella burnetii</option>
<option value="CRYNJ">Cryptococcus neoformans</option>
<option value="CUCSA">Cucumis sativus</option>
<option value="DAPPU">Daphnia pulex</option>
<option value="DEIRA">Deinococcus radiodurans</option>
<option value="DICTD">Dictyoglomus turgidum</option>
<option value="DICPU">Dictyostelium purpureum</option>
<option value="ENTHI">Entamoeba histolytica</option>
<option value="HORSE">Equus caballus</option>
<option value="ERYGU">Erythranthe guttata</option>
<option value="FELCA">Felis catus</option>
<option value="FUSNN">Fusobacterium nucleatum</option>
<option value="GEOSL">Geobacter sulfurreducens</option>
<option value="GIAIC">Giardia intestinalis</option>
<option value="GLOVI">Gloeobacter violaceus</option>
<option value="SOYBN">Glycine max</option>
<option value="GORGO">Gorilla gorilla gorilla</option>
<option value="GOSHI">Gossypium hirsutum</option>
<option value="HAEIN">Haemophilus influenzae</option>
<option value="HALSA">Halobacterium salinarum</option>
<option value="HELAN">Helianthus annuus</option>
<option value="HELPY">Helicobacter pylori</option>
<option value="HORVV">Hordeum vulgare subsp. vulgare</option>
<option value="IXOSC">Ixodes scapularis</option>
<option value="KORCO">Korarchaeum cryptofilum</option>
<option value="LEIMA">Leishmania major</option>
<option value="LEPIN">Leptospira interrogans</option>
<option value="LISMO">Listeria monocytogenes</option>
<option value="MACMU">Macaca mulatta</option>
<option value="MEDTR">Medicago truncatula</option>
<option value="METJA">Methanocaldococcus jannaschii</option>
<option value="METAC">Methanosarcina acetivorans</option>
<option value="MONDO">Monodelphis domestica</option>
<option value="MONBE">Monosiga brevicollis</option>
<option value="MUSAM">Musa acuminata subsp. malaccensis</option>
<option value="MYCTU">Mycobacterium tuberculosis</option>
<option value="NEIMB">Neisseria meningitidis serogroup b</option>
<option value="NEMVE">Nematostella vectensis</option>
<option value="ASPFU">Neosartorya fumigata</option>
<option value="NEUCR">Neurospora crassa</option>
<option value="TOBAC">Nicotiana tabacum</option>
<option value="NITMS">Nitrosopumilus maritimus</option>
<option value="ORNAN">Ornithorhynchus anatinus</option>
<option value="ORYSJ">Oryza sativa</option>
<option value="ORYLA">Oryzias latipes</option>
<option value="OSTTA">Ostreococcus tauri</option>
<option value="PANTR">Pan troglodytes</option>
<option value="PARTE">Paramecium tetraurelia</option>
<option value="PHANO">Phaeosphaeria nodorum</option>
<option value="PHODC">Phoenix dactylifera</option>
<option value="PHYPA">Physcomitrella patens</option>
<option value="PHYRM">Phytophthora ramorum</option>
<option value="PLAF7">Plasmodium falciparum</option>
<option value="POPTR">Populus trichocarpa</option>
<option value="PRIPA">Pristionchus pacificus</option>
<option value="PRUPE">Prunus persica</option>
<option value="PSEAE">Pseudomonas aeruginosa</option>
<option value="PUCGT">Puccinia graminis</option>
<option value="PYRAE">Pyrobaculum aerophilum</option>
<option value="RHOBA">Rhodopirellula baltica</option>
<option value="RICCO">Ricinus communis</option>
<option value="SALTY">Salmonella typhimurium</option>
<option value="SCLS1">Sclerotinia sclerotiorum</option>
<option value="SETIT">Setaria italica</option>
<option value="SHEON">Shewanella oneidensis</option>
<option value="SOLLC">Solanum lycopersicum</option>
<option value="SORBI">Sorghum bicolor</option>
<option value="STAA8">Staphylococcus aureus</option>
<option value="STRR6">Streptococcus pneumoniae</option>
<option value="STRCO">Streptomyces coelicolor</option>
<option value="STRPU">Strongylocentrotus purpuratus</option>
<option value="SULSO">Sulfolobus solfataricus</option>
<option value="PIG">Sus scrofa</option>
<option value="SYNY3">Synechocystis</option>
<option value="THAPS">Thalassiosira pseudonana</option>
<option value="THECC">Theobroma cacao</option>
<option value="THEKO">Thermococcus kodakaraensis</option>
<option value="THEYD">Thermodesulfovibrio yellowstonii</option>
<option value="THEMA">Thermotoga maritima</option>
<option value="TRICA">Tribolium castaneum</option>
<option value="TRIVA">Trichomonas vaginalis</option>
<option value="TRIAD">Trichoplax adhaerens</option>
<option value="WHEAT">Triticum aestivum</option>
<option value="TRYB2">Trypanosoma brucei</option>
<option value="USTMA">Ustilago maydis</option>
<option value="VIBCH">Vibrio cholerae</option>
<option value="VITVI">Vitis vinifera</option>
<option value="XANCP">Xanthomonas campestris</option>
<option value="XENTR">Xenopus tropicalis</option>
<option value="YARLI">Yarrowia lipolytica</option>
<option value="YERPE">Yersinia pestis</option>
<option value="MAIZE">Zea mays</option>
<option value="HELRO">helobdella robusta</option>
<option value="LEPOC">lepisosteus oculatus</option>
<option value="MYCGE">mycoplasma genitalium</option>
</select>
</div>
<span class="input-group-btn">
<button type="button" class="btn btn-primary u-no-transform u-anim-zoom-in" style="background-color: #22612C; border-color: #22612C; margin-left: 4px;" onclick="setExample()" title="Cycle through different Gene Set examples">
Examples
</button>
<button type="submit" class="btn btn-primary u-no-transform u-anim-move-right" style="background-color: #22612C; border-color: #22612C; margin-left: 4px;" title="Launch GO Enrichment Analysis">
Launch <i class="fa-solid fa-chevron-right u-line-height-single"></i>
</button>
</span>
</div>
<div id="input_hint" class="input_hint">Hint: can use UniProt ID/AC, Gene Name, Gene Symbols, MOD IDs</div>
</form>
</div>
<!-- <div class="hidden-xs hidden-sm">
<img src="img/go-logo-icon.png" alt="Gene Ontology Logo" class="img-responsive go-main-logo" style="margin: auto;">
</div> -->
<div style="
border-radius: 35px 10px 35px 10px;
padding: 20px;
padding-top: 1px;
margin-top: 20px;
font-size: 16px;
color: black;
">
<!-- <h3 style="font-size: 25px;margin-bottom: 0px;">
<a href="/docs/downloads/">Current Release: 2018-10-08 <i class="fa-solid fa-question-circle"></i></a>
</h3>
<li>45 042 GO terms</li>
<li>6 278 639 annotations</li>
<li>3 200 species</li> -->
</div>
</div>
</div>
</div>
<hr style="margin:0px; padding:0px">
</div>
<div class="container"
style="margin-right: auto;
margin-left: auto;
padding-left: 0px;
padding-right: 0px;
width: 98%;
max-width: 1500px;">
<div class="row">
<div class="card col-md-3">
<div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);">
<div onclick="location.href = '/docs/ontology-documentation/'" class="card__picture card__picture__dna--red">
<h4 class="card__heading"><i class="fa-solid fa-share-nodes"></i> Ontology</h4>
</div>
<p class="card__description">
The network of biological classes describing the current best representation of the “universe” of biology: the molecular
functions, cellular locations, and processes gene products may carry out.
</p>
<div class="card__bottom">
<div>
<a href="/docs/ontology-documentation/" class="card__link">
<i class="fa-solid fa-info"></i> GO Ontology Overview</a>
</div>
<div>
<a href="https://amigo.geneontology.org/amigo/dd_browse" class="card__link" target="blank">
<i class="fa-regular fa-clone"></i> Browse in AmiGO</a>
</div>
<div>
<a href="/docs/download-ontology/" class="card__link">
<i class="fa-solid fa-download"></i> Download</a>
</div>
</div>
</div>
</div>
<div class="card col-md-3">
<div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);">
<div onclick="location.href = '/docs/go-annotations/'" class="card__picture card__picture__standard-annotation">
<h4 class="card__heading"><i class="fa-solid fa-edit"></i> Annotation</h4>
</div>
<p class="card__description">
Statements, based on specific, traceable scientific evidence, asserting that a specific gene product is a real exemplar of
a particular GO class.
</p>
<div class="card__bottom">
<div>
<a href="/docs/go-annotations/" class="card__link">
<i class="fa-solid fa-info"></i> GO Annotations Overview</a>
</div>
<div>
<a href="https://amigo.geneontology.org/amigo/search/annotation" class="card__link" target="blank">
<i class="fa-regular fa-clone"></i> Browse in AmiGO</a>
</div>
<div>
<a href="/docs/download-go-annotations/" class="card__link" target="blank">
<i class="fa-solid fa-download"></i> Download</a>
</div>
</div>
</div>
</div>
<div class="card col-md-3">
<div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);">
<div onclick="location.href = '/docs/gocam-overview/'" class="card__picture card__picture__gocam">
<h4 class="card__heading"><i class="fa-solid fa-cog"></i> GO-CAM</h4>
</div>
<p class="card__description">
GO Causal Activity Model (GO-CAM) provides a structured framework to link standard GO annotations into a more complete model of a biological system.
</p>
<div class="card__bottom">
<div>
<a href="/docs/gocam-overview/" class="card__link">
<i class="fa-solid fa-info"></i> GO-CAM Overview</a>
</div>
<div>
<a href="http://geneontology.org/go-cam" class="card__link">
<i class="fa-regular fa-clone"></i> Browse GO-CAMs</a>
</div>
<div>
<a href="/docs/download-go-cams/" class="card__link">
<i class="fa-solid fa-download"></i> Download</a>
</div>
</div>
</div>
</div>
<div class="card col-md-3">
<div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);">
<div onclick="location.href = '/docs/tools-overview/'" class="card__picture card__picture__dna--green">
<h4 class="card__heading"><i class="fa-solid fa-cog"></i> Tools & Guides</h4>
</div>
<p class="card__description">
Tools to curate, browse, search, visualize and download both the ontology and annotations. Includes bioinformatic guides (Notebooks) and simple API access to integrate the GO into your research.
</p>
<div class="card__bottom">
<div>
<a href="/docs/tools-overview/" class="card__link">
<i class="fa-solid fa-info"></i> GO Tools Overview</a>
</div>
<div>
<a href="/docs/tools-guide/" class="card__link">
<i class="fa-regular fa-clone"></i> GO APIs Guide</a>
</div>
<div>
<a href="https://github.com/geneontology/" class="card__link" target="blank">
<i class="fa-brands fa-github"></i> GO GitHub</a>
</div>
</div>
</div>
</div>
</div>
<br>
<br>