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Add group-wise calling #21

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j-andrews7 opened this issue Dec 31, 2024 · 2 comments
Open

Add group-wise calling #21

j-andrews7 opened this issue Dec 31, 2024 · 2 comments

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@j-andrews7
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Get coverage for all peaks in groups (named list of objects/paths), optionally use recurrent peaks across peaks within groups for filtering, perform SE calling.

This could also allow multiple samples to be run at once by passing them in via a list.

Length of signal and peaks lists must match, as should the names of the elements.

@j-andrews7
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j-andrews7 commented Jan 6, 2025

Probably use rmspc to generate consensus peak sets for a group.

Ensure it's using the appropriate column for the p-values, as mentioned here.

@j-andrews7
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j-andrews7 commented Jan 13, 2025

Implement alternative method for iterative overlap of peaks, a la ArchR. See this discussion also.

This method would be arguably less stringent than rmspc and requires fixed-width peaks, but it may be helpful for SE calling from ATAC or TFs, etc, and would enable some other experimenting.

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