diff --git a/lib/galaxy/model/__init__.py b/lib/galaxy/model/__init__.py
index 4efa7174d79d..6c49dc020cb5 100644
--- a/lib/galaxy/model/__init__.py
+++ b/lib/galaxy/model/__init__.py
@@ -3705,6 +3705,7 @@ def __init__(self, user, role):
 
 class GroupRoleAssociation(Base, RepresentById):
     __tablename__ = "group_role_association"
+    __table_args__ = (UniqueConstraint("group_id", "role_id"),)
 
     id: Mapped[int] = mapped_column(primary_key=True)
     group_id: Mapped[int] = mapped_column(ForeignKey("galaxy_group.id"), index=True, nullable=True)