diff --git a/doc/source/whatsnew/v2.3.1.rst b/doc/source/whatsnew/v2.3.1.rst
index 64e5c1510e1da..eb3ad72f6a59f 100644
--- a/doc/source/whatsnew/v2.3.1.rst
+++ b/doc/source/whatsnew/v2.3.1.rst
@@ -59,6 +59,7 @@ Bug fixes
 - Bug in :meth:`.DataFrameGroupBy.min`, :meth:`.DataFrameGroupBy.max`, :meth:`.Resampler.min`, :meth:`.Resampler.max` where all NA values of string dtype would return float instead of string dtype (:issue:`60810`)
 - Bug in :meth:`DataFrame.sum` with ``axis=1``, :meth:`.DataFrameGroupBy.sum` or :meth:`.SeriesGroupBy.sum` with ``skipna=True``, and :meth:`.Resampler.sum` with all NA values of :class:`StringDtype` resulted in ``0`` instead of the empty string ``""`` (:issue:`60229`)
 - Fixed bug in :meth:`DataFrame.explode` and :meth:`Series.explode` where methods would fail with ``dtype="str"`` (:issue:`61623`)
+- Fixed bug in unpickling objects pickled in pandas versions pre-2.3.0 that used :class:`StringDtype` (:issue:`61763`).
 
 
 .. _whatsnew_231.regressions:
@@ -72,7 +73,6 @@ Fixed regressions
 
 Bug fixes
 ~~~~~~~~~
--
 
 .. ---------------------------------------------------------------------------
 .. _whatsnew_231.other:
diff --git a/pandas/core/arrays/string_.py b/pandas/core/arrays/string_.py
index 0cd989ab9464c..9c8dc2054106a 100644
--- a/pandas/core/arrays/string_.py
+++ b/pandas/core/arrays/string_.py
@@ -69,6 +69,8 @@
 from pandas.io.formats import printing
 
 if TYPE_CHECKING:
+    from collections.abc import MutableMapping
+
     import pyarrow
 
     from pandas._typing import (
@@ -213,6 +215,11 @@ def __eq__(self, other: object) -> bool:
             return self.storage == other.storage and self.na_value is other.na_value
         return False
 
+    def __setstate__(self, state: MutableMapping[str, Any]) -> None:
+        # back-compat for pandas < 2.3, where na_value did not yet exist
+        self.storage = state.pop("storage", "python")
+        self._na_value = state.pop("_na_value", libmissing.NA)
+
     def __hash__(self) -> int:
         # need to override __hash__ as well because of overriding __eq__
         return super().__hash__()
diff --git a/pandas/tests/io/data/legacy_pickle/1.5.3/1.5.3_x86_64_win_3.11.13.pickle b/pandas/tests/io/data/legacy_pickle/1.5.3/1.5.3_x86_64_win_3.11.13.pickle
new file mode 100644
index 0000000000000..d12fc5929ea5b
Binary files /dev/null and b/pandas/tests/io/data/legacy_pickle/1.5.3/1.5.3_x86_64_win_3.11.13.pickle differ
diff --git a/pandas/tests/io/data/legacy_pickle/2.0.3/2.0.3_AMD64_windows_3.11.12.pickle b/pandas/tests/io/data/legacy_pickle/2.0.3/2.0.3_AMD64_windows_3.11.12.pickle
new file mode 100644
index 0000000000000..f508272d058f9
Binary files /dev/null and b/pandas/tests/io/data/legacy_pickle/2.0.3/2.0.3_AMD64_windows_3.11.12.pickle differ
diff --git a/pandas/tests/io/data/legacy_pickle/2.1.4/2.1.4_AMD64_windows_3.11.12.pickle b/pandas/tests/io/data/legacy_pickle/2.1.4/2.1.4_AMD64_windows_3.11.12.pickle
new file mode 100644
index 0000000000000..6f838839c2937
Binary files /dev/null and b/pandas/tests/io/data/legacy_pickle/2.1.4/2.1.4_AMD64_windows_3.11.12.pickle differ
diff --git a/pandas/tests/io/data/legacy_pickle/2.2.3/2.2.3_AMD64_windows_3.11.12.pickle b/pandas/tests/io/data/legacy_pickle/2.2.3/2.2.3_AMD64_windows_3.11.12.pickle
new file mode 100644
index 0000000000000..f98766fd4e05d
Binary files /dev/null and b/pandas/tests/io/data/legacy_pickle/2.2.3/2.2.3_AMD64_windows_3.11.12.pickle differ
diff --git a/pandas/tests/io/generate_legacy_storage_files.py b/pandas/tests/io/generate_legacy_storage_files.py
index 9bfd8eb9d51d5..9cb50b03e223a 100644
--- a/pandas/tests/io/generate_legacy_storage_files.py
+++ b/pandas/tests/io/generate_legacy_storage_files.py
@@ -147,6 +147,7 @@ def create_pickle_data():
         "float": Index(np.arange(10, dtype=np.float64)),
         "uint": Index(np.arange(10, dtype=np.uint64)),
         "timedelta": timedelta_range("00:00:00", freq="30min", periods=10),
+        "string": Index(["foo", "bar", "baz", "qux", "quux"], dtype="string"),
     }
 
     index["range"] = RangeIndex(10)
@@ -185,6 +186,7 @@ def create_pickle_data():
         "dt": Series(date_range("20130101", periods=5)),
         "dt_tz": Series(date_range("20130101", periods=5, tz="US/Eastern")),
         "period": Series([Period("2000Q1")] * 5),
+        "string": Series(["foo", "bar", "baz", "qux", "quux"], dtype="string"),
     }
 
     mixed_dup_df = DataFrame(data)
@@ -233,6 +235,12 @@ def create_pickle_data():
             },
             index=range(5),
         ),
+        "string": DataFrame(
+            {
+                "A": Series(["foo", "bar", "baz", "qux", "quux"], dtype="string"),
+                "B": Series(["one", "two", "one", "two", "three"], dtype="string"),
+            }
+        ),
     }
 
     cat = {
diff --git a/pyproject.toml b/pyproject.toml
index 899bcfca35939..085d5c3bce07a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -526,6 +526,8 @@ filterwarnings = [
   "ignore:distutils Version classes are deprecated:DeprecationWarning:fsspec",
   # Can be removed once https://github.com/numpy/numpy/pull/24794 is merged
   "ignore:.*In the future `np.long` will be defined as.*:FutureWarning",
+  # https://github.com/numpy/numpy/pull/29301
+  "ignore:.*align should be passed:",
 ]
 junit_family = "xunit2"
 markers = [