diff --git a/.changeset/deep-impalas-wave.md b/.changeset/deep-impalas-wave.md
new file mode 100644
index 00000000000..4a6d5de55cf
--- /dev/null
+++ b/.changeset/deep-impalas-wave.md
@@ -0,0 +1,5 @@
+---
+'@primer/react': patch
+---
+
+Change actionlist item inline description styling from flex to block to fix overflow
diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-colorblind-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-colorblind-linux.png
index abc58e7d55f..0ab014fbe3a 100644
Binary files a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-colorblind-linux.png and b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-colorblind-linux.png differ
diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-dimmed-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-dimmed-linux.png
index 296383338e1..800c76f703d 100644
Binary files a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-dimmed-linux.png and b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-dimmed-linux.png differ
diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-high-contrast-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-high-contrast-linux.png
index dde2d5f7286..b9fb89e9c69 100644
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diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-linux.png
index abc58e7d55f..0ab014fbe3a 100644
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diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-tritanopia-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-dark-tritanopia-linux.png
index abc58e7d55f..0ab014fbe3a 100644
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diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-colorblind-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-colorblind-linux.png
index a24621ccb8d..63dfc9a5977 100644
Binary files a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-colorblind-linux.png and b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-colorblind-linux.png differ
diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-high-contrast-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-high-contrast-linux.png
index 363c849ade0..5059d67cc92 100644
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diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-linux.png
index a24621ccb8d..63dfc9a5977 100644
Binary files a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-linux.png and b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-linux.png differ
diff --git a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-tritanopia-linux.png b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-tritanopia-linux.png
index a24621ccb8d..63dfc9a5977 100644
Binary files a/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-tritanopia-linux.png and b/.playwright/snapshots/components/ActionList.test.ts-snapshots/ActionList-All-combinations-light-tritanopia-linux.png differ
diff --git a/packages/react/src/ActionList/ActionList.module.css b/packages/react/src/ActionList/ActionList.module.css
index f8007fb3e63..9cc0d09eef7 100644
--- a/packages/react/src/ActionList/ActionList.module.css
+++ b/packages/react/src/ActionList/ActionList.module.css
@@ -628,27 +628,23 @@ default block */
   /* inline */
   &:where([data-description-variant='inline']) {
     position: relative;
+    display: block;
     word-break: normal;
-    flex-direction: row;
-    align-items: baseline;
-    gap: var(--base-size-8);
+    /* stylelint-disable-next-line primer/typography */
+    line-height: normal;
 
     & .ItemLabel {
       word-break: normal;
     }
 
-    &:has([data-truncate='true']) {
-      & .ItemLabel {
-        flex: 1 0 auto;
-      }
-    }
-
     & .Description {
+      margin-left: var(--base-size-8);
       /* adjust line-height for baseline alignment */
 
       /* line-height: calc(var(--control-medium-lineBoxHeight) - var(--base-size-2)); */
       /* stylelint-disable-next-line primer/typography */
       line-height: 16px;
+      overflow-wrap: break-word;
     }
   }
 }