diff --git a/pyproject.toml b/pyproject.toml
index 1384202e..f42d72d5 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -44,6 +44,9 @@ imaging = [
 homepage = "https://github.com/rsagroup/rsatoolbox"
 documentation = "https://rsatoolbox.readthedocs.io/"
 
+[project.scripts]
+rsatoolbox = "rsatoolbox.cli:main"
+
 [tool.setuptools_scm]
 local_scheme = "no-local-version"
 
diff --git a/src/rsatoolbox/cli.py b/src/rsatoolbox/cli.py
new file mode 100644
index 00000000..6caa1daa
--- /dev/null
+++ b/src/rsatoolbox/cli.py
@@ -0,0 +1,100 @@
+"""Command Line Interface
+
+Usage output:
+```
+Representational Similarity Analysis
+
+positional arguments:
+  file                  One or more files or directories with data
+
+options:
+  -h, --help            show this help message and exit
+  --version             show program's version number and exit
+  --model MODEL         File with RDM models
+  --estimator {auto,euclidean,correlation,mahalanobis,crossnobis,poisson,poisson_cv}
+                        Which dissimilarity measure to generate RDM with
+  --comparator {auto,cosine,spearman,corr,kendall,tau-a,rho-a,corr_cov,cosine_cov,neg_riem_dist,bures,bures_metric}
+                        Which method to use when evaluating models or comparing RDMs
+  --searchlight SEARCHLIGHT
+                        Run a searchlight over the whole space with the given radius. Unit depends on data modality.
+  --window [WINDOW ...]
+                        Boundaries of a temporal window in milliseconds, e.g. "150 200"
+  --roi [ROI ...]       One or more "mask" or "picks" files to specify voxel or channel selection
+```
+
+"""
+from argparse import ArgumentParser
+from importlib.metadata import version
+
+parser = ArgumentParser(
+    prog='rsatoolbox',
+    description='Representational Similarity Analysis'
+)
+parser.add_argument(
+    'file',
+    default='.',
+    help='One or more files or directories with data',
+    nargs='*',
+)
+parser.add_argument(
+    '--version',
+    action='version',
+    version=f'rsatoolbox {version("rsatoolbox")}'
+)
+parser.add_argument(
+    '--model',
+    help='File with RDM models',
+)
+parser.add_argument(
+    '--estimator',
+    help='Which dissimilarity measure to generate RDM with',
+    choices=[
+        'auto',
+        'euclidean',
+        'correlation',
+        'mahalanobis',
+        'crossnobis',
+        'poisson',
+        'poisson_cv',
+    ],
+    default='auto',
+)
+parser.add_argument(
+    '--comparator',
+    help='Which method to use when evaluating models or comparing RDMs',
+    choices=[
+        'auto',
+        'cosine',
+        'spearman',
+        'corr',
+        'kendall',
+        'tau-a',
+        'rho-a',
+        'corr_cov',
+        'cosine_cov',
+        'neg_riem_dist',
+        'bures',
+        'bures_metric',
+    ],
+    default='auto',
+)
+parser.add_argument(
+    '--searchlight',
+    help='Run a searchlight over the whole space with the given radius. Unit depends on data modality.',
+    type=int,
+    default=0,
+)
+parser.add_argument(
+    '--window',
+    help='Boundaries of a temporal window in milliseconds, e.g. "150 200"',
+    nargs='*',
+)
+parser.add_argument(
+    '--roi',
+    help='One or more "mask" or "picks" files to specify voxel or channel selection',
+    nargs='*',
+)
+
+
+def main():
+    parser.parse_args()