diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 8263ff9..a4e25ff 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -21,7 +21,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        tox_env: [py39, py310,  py311,  py312,  py313, pypy3, pep8]
+        tox_env: [py39, py310,  py311,  py312,  py313, pypy3]
 
     # Use GitHub's Linux Docker host
     runs-on: ubuntu-latest
@@ -32,23 +32,15 @@ jobs:
       - uses: actions/checkout@v4
         with:
           fetch-depth: 0
-      - name: Install ruff
-        run: |
-          python3 -m pip install --break-system-packages ruff mypy
+      - name: Install tox
+        run: python -m pip install tox
       - name: Run ruff format
         run: |
-          ruff --version
-          if ! ruff format --check --quiet varlink
-          then
-              echo "Please run 'ruff format' on the above files or apply the diffs below manually"
-              ruff format --check --quiet --diff varlink
-          fi
+          tox -e ruff-format
       - name: Run ruff check
         run: |
-          ruff --version
-          ruff check varlink
+          tox -e ruff-check
       - name: Type Checking (mypy)
         run: |
-          python3 -m mypy --version
-          python3 -m mypy varlink/
+          tox -e mypy
     runs-on: ubuntu-latest
diff --git a/pyproject.toml b/pyproject.toml
index fe76d54..d18bfe5 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -13,3 +13,46 @@ local_scheme = "no-local-version"
 target-version = "py39"
 line-length = 109
 lint.select = ["E", "F", "I", "UP"]
+
+[tool.mypy]
+python_version = 3.9
+
+### tox configuration ###
+[tool.tox]
+env_list = ["py313", "py312", "py311", "py310", "py39", "pypy3"]
+
+[tool.tox.env_run_base]
+description = "Run test suite on {base_python}"
+deps = ["-r{toxinidir}/test-requirements.txt"]
+commands = [
+    ["pytest", "--cov=varlink", "--cov-report=term", "{posargs:varlink}"]
+]
+
+[tool.tox.env_run_base.set_env]
+VIRTUAL_ENV="{envdir}"
+BRANCH_NAME="master"
+CLIENT_NAME="varlink"
+
+[tool.tox.env.ruff-format]
+description = "Check formatting using the ruff tool"
+deps = ["ruff"]
+commands = [
+    ["ruff", "--version"],
+    ["ruff", "format", "--quiet", "--check", "--diff", "{posargs:varlink}"]
+]
+
+[tool.tox.env.ruff-check]
+description = "Run linting checks using the ruff tool"
+deps = ["ruff"]
+commands = [
+    ["ruff", "--version"],
+    ["ruff", "check", "{posargs:varlink}"]
+]
+
+[tool.tox.env.mypy]
+description = "Run type checking tool mypy"
+deps = ["mypy"]
+commands = [
+    ["mypy", "--version"],
+    ["mypy", "{posargs:varlink}"]
+]
diff --git a/test-requirements.txt b/test-requirements.txt
index 7696e32..9955dec 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -1,2 +1,2 @@
-fixtures
-nose2
+pytest
+pytest-cov
diff --git a/tox.ini b/tox.ini
deleted file mode 100644
index 7f72306..0000000
--- a/tox.ini
+++ /dev/null
@@ -1,20 +0,0 @@
-# tox (https://tox.readthedocs.io/) is a tool for running tests
-# in multiple virtualenvs. This configuration file will run the
-# test suite on all supported python versions. To use it, "pip install tox"
-# and then run "tox" from this directory.
-
-[tox]
-envlist = py313,py312,py311,py310,py39,pep8,pypy3
-
-[testenv]
-usedevelop = True
-install_command = pip install {opts} {packages}
-setenv =
-    VIRTUAL_ENV={envdir}
-    BRANCH_NAME=master
-    CLIENT_NAME=varlink
-deps =
-    -r{toxinidir}/test-requirements.txt
-commands =
-    nose2 \
-    --coverage varlink