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35 changes: 35 additions & 0 deletions README.md
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# NEURON mod files for the I-A current from the paper:

Beck H, Ficker E, Heinemann U.
Properties of two voltage-activated potassium currents in acutely isolated juvenile rat dentate gyrus granule cells.
*J. Neurophysiol.* 68, 2086-2099 (1992)

Running the kinetics.hoc simulation file will show the activation and inactivation steady-states, the time constants, and a family of curves generated modeling the same protocols used in the experiments for Figs.3A-3C of the paper.

According to this paper, the kinetic parameters change with development. The values used in this model are those needed to reproduce the experimental findings of Fig.3.

The time constants reported in the paper are shown as markers of different color. Time constants in the range not covered by the paper and activation kinetics have been adjusted to give a reasonable approximation of the voltage-clamp current traces in Figs.3A-3C.

## Instructions for compilation and running

### Under Unix systems:

To compile the mod files use the command:
`nrnivmodl`

And run the simulation hoc file with the command:
`nrngui kinetics.hoc`

### Under Windows using NEURON 5.1:

To compile the mod files use the "mknrndll" command.
A double click on the simulation file
`kinetics.hoc`
will open the simulation window.

Questions on how to use this model should be directed to:
[email protected]

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2025-05-27 – Standardized to Markdown.
36 changes: 0 additions & 36 deletions readme.txt

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