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23 changes: 14 additions & 9 deletions readme.txt → readme.md
Original file line number Diff line number Diff line change
@@ -1,34 +1,39 @@
NEURON mod files for the K-A current from the papers:
Benison et al., J.Theor.Biol. 210:187 (2001) (model) and
Skaliora, et al., Eur.J.Neurosci. 7:1558-1568 (1995) (exp.).
Skaliora, et al., *Eur.J.Neurosci*. 7:1558-1568 (1995) (exp.).

Running the kinetics.hoc simulation file will show
- Running the kinetics.hoc simulation file will show
the activation and inactivation steady-states, the time constants,
and a family of curves generated modeling the same protocols
used for Figs.8B of the experimental paper.

The kinetic parameters used here are from the modeling paper.
- The kinetic parameters used here are from the modeling paper.
They where chosen by the authors to fit the time course
of the current obtained from whole-cell data in their own
laboratory (experimental paper).

The peak conductance has been adjusted to give approximately the
- The peak conductance has been adjusted to give approximately the
same peak currents shown in the experiments.

Under unix systems:
## Under unix systems:
to compile the mod files use the command
nrnivmodl
``` nrnivmodl ```
and run the simulation hoc file with the command
nrngui kinetics.hoc
``` nrngui kinetics.hoc ```

Under Windows using NEURON 5.1:
to compile the mod files use the "mknrndll" command.
## vUnder Windows using NEURON 5.1:
to compile the mod files use the ``` mknrndll ``` command.
A double click on the simulation file
kinetics.hoc
will open the simulation window.

\
Questions on the model parameters should be directed to the
authors of the modeling paper.

Questions on how to use this model with NEURON
should be directed to [email protected]

Changelog:
----------
2024-10: Converted readme to markdown