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43 changes: 43 additions & 0 deletions README.md
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# NEURON mod files for the K-A current

From the papers:
Benison et al., *J. Theor. Biol.* 210:187 (2001) (model) and
Skaliora, et al., *Eur. J. Neurosci.* 7:1558-1568 (1995) (exp.).

Running the **kinetics.hoc** simulation file will show
the activation and inactivation steady-states, the time constants,
and a family of curves generated modeling the same protocols
used for Figs. 8B of the experimental paper.

The kinetic parameters used here are from the modeling paper.
They were chosen by the authors to fit the time course
of the current obtained from whole-cell data in their own
laboratory (experimental paper).

The peak conductance has been adjusted to give approximately the
same peak currents shown in the experiments.

## Under Unix systems:

To compile the mod files use the command
`nrnivmodl`

and run the simulation hoc file with the command
`nrngui kinetics.hoc`

## Under Windows using NEURON 5.1:

To compile the mod files use the **mknrndll** command.
A double click on the simulation file
**kinetics.hoc**
will open the simulation window.

Questions on the model parameters should be directed to the
authors of the modeling paper.

Questions on how to use this model with NEURON
should be directed to [email protected]

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2025-05-27 – Standardized to Markdown
34 changes: 0 additions & 34 deletions readme.txt

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