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48 changes: 48 additions & 0 deletions README.md
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# NEURON mod files for the Na, K-A, and K-DR currents

from the paper:
Safronov and Vogel, *J.Physiol.* 487:91-106 (1995).

Running the `kinetics_na.hoc` or `kinetics_k.hoc` simulation files will show the activation and inactivation steady-states, the time constants, and a family of curves generated modeling the same protocols used in the paper.

Markers show the experimental values estimated from Figs.4C (Na), 8C (KA), and 10C (KDR) of the paper.
Note that *m* is used rather than the more usual *m*³ for activation of the Na current. Na recovery from inactivation is not implemented.

---

## Under Unix systems:

- To compile the mod files use the command:

```
nrnivmodl
```

- Run the simulation hoc file with the command:

```
nrngui kinetics_na.hoc
```

or

```
nrngui kinetics_k.hoc
```

---

## Under Windows using NEURON 5.1:

- To compile the mod files use the "mknrndll" command.
- Double-click on the simulation files `kinetics_na.hoc` or `kinetics_k.hoc` will open the simulation windows.

---

Questions on the model parameters should be directed to the authors.

Questions on how to use this model with NEURON should be directed to [email protected]

---

2025-05-27 – Standardized to Markdown.
33 changes: 0 additions & 33 deletions readme.txt

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